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Topic: Specificity of Cholinergic Drugs  (Read 9887 times)

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Offline AhmedEzatAlzawalaty

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Specificity of Cholinergic Drugs
« on: November 12, 2007, 06:49:43 PM »
i want to know what makes any drug specific to a certain receptor from chemical pont of view,i wanna talk here about cholinergic drugs that i  studied ,Methacholine is specific to M2 in Heart why? what chemical basis that explains this.
Also carbachol is not specific acting on both Ng and M in GIT and eye ,bethanechol is specific to M in GIT and Eye too but not acting on Ng, i want any one to explains all this stuff based on chemical basis.
I want also to know why Physostigmine passes Blood Brain Barrier while Neostigmine which does not have CNS activity,does not.

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