[Mikez]

I have a question asking me to compare normal hemoglobin and sickle hemoglobin at the fourth level of protein structure but asks for any changes in "sum of all folded protein chains"?

I don't understand what it means by the phrase sum of all folded protein chains.

thanks

[Yggdrasil]

My best guess is that the question is asking about differences in how normal hemoglobin polypeptide chains assemble into their quarternary structure v. how sickle cell hemoglobin chains assemble.