April 18, 2024, 03:10:02 PM
Forum Rules: Read This Before Posting


« previous next »
Pages: [1]   Go Down

Topic: amide to amino alcohol  (Read 5114 times)

0 Members and 1 Guest are viewing this topic.

Offline absbhai

  • New Member
  • **
  • Posts: 5
  • Mole Snacks: +0/-0
amide to amino alcohol
« on: January 23, 2008, 07:43:08 AM »
hi. I want to reduce an amide to amino alcohol. How can i stop the reaction before the amide can end up as amine?
Logged

Offline sjb

  • Global Moderator
  • Sr. Member
  • ***
  • Posts: 3652
  • Mole Snacks: +222/-42
  • Gender: Male
Re: amide to amino alcohol
« Reply #1 on: January 24, 2008, 02:45:28 AM »
I'm a little confused as to what you mean here, first you want to reduce the amide to an amino alcohol, then without forming the amine??

Do you mean a 1,1-aminoalcohol (a bit like RCONHR'R'' -> RCH(OH)NR'R'' ) with the alcohol and amine on the same carbon?
Logged

Offline absbhai

  • New Member
  • **
  • Posts: 5
  • Mole Snacks: +0/-0
Re: amide to amino alcohol
« Reply #2 on: January 24, 2008, 08:37:52 AM »
sorry mate. i guess i got the wrong nomenclature. What i want is to reduce the amide to aminal. something like RC(O)NHMe to RCH(OH)NHMe. the standard procedures for reduction that i was able to dig up, all lead to the formation of an amine RCH2NHMe. Any sugesstions please
Logged

Offline AWK

  • Retired Staff
  • Sr. Member
  • *
  • Posts: 7979
  • Mole Snacks: +555/-93
  • Gender: Male
Re: amide to amino alcohol
« Reply #3 on: January 24, 2008, 11:50:39 AM »
You have little or no chance. Aminals with free OH groups are extremely unstable.
Logged
AWK
Pages: [1]   Go Up
« previous next »
Sponsored Links