[lutesium]

Dear Sir/Ma'am

How can this reagent be synthesised???


Thank you!!!

[Kryolith]

http://en.wikipedia.org/wiki/Diazomethane
http://www.orgsynth.com/orgsyn/orgsyn/prepContent.asp?prep=CV5P0351
http://www.orgsynth.com/orgsyn/orgsyn/prepContent.asp?prep=cv2p0165

I once prepared it from N-methyl-N-nitroso urea... works fine

[movies]

Diazomethane is a very hazardous chemical!  If you don't absolutely need it, don't make it.

[Kryolith]

You can handle it well in diluted solution (pure diazomethane is a gas). Of course safety measures are obligatory. My main problem was, that I didn't know the exact concentration of the solution I prepared...

[movies]

True, but even in solution it is shock sensitive and can detonate if it comes into contact with a rough surface.

[lutesium]

I know it even with glass stoppers it might explode but I don't mind it!!! Because I am going to try to make it in stiu!!! And what about the other diazo-alkanes??? DiazoButane maybe???


Lutesium...

[sjh9]

I have prepared it from diazald (see Aldrich) using a diazomethane kit.  This has smooth glass joints.  The result is a solution in diethyl ether.  Titration will benzoic acid can determine the final concentration.

However, I recommend a solid suppored diazomethane equivalent:
http://www.emd.com/product/01-64-0413

[Kryolith]

Titration will benzoic acid can determine the final concentration.

...if CH₂N₂ would stay in solution.

[russellm72]

Hi,

I've made it C-14 labelled so it aint that bad!

Lutesium what do you need it for?

R.

[lutesium]

Actually I need to make diazo-butane or diazo-ethane for an alkylation of a very precious molecule for the syntheis of a new D2 dopamine agonist (ergoline type) and if you know ergoline chemistry they are very precious and fragile!!!


Thanks!!!