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Topic: solvent extraction  (Read 3111 times)

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Offline laserni

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solvent extraction
« on: September 25, 2009, 02:14:40 PM »
I am running a reaction in neat TFA. After completion, I've neutralised excess TFA by NaOH and then extracted the aqueous layer with dichloromethane and dried over Mag sulfate. However, when I'm trying to dissolve the resulting residue in DMSO-d6 or CDCl3, it is forming a suspension rather than a clear solution. Could you please help me to fix this?

Offline gfunk

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Re: solvent extraction
« Reply #1 on: September 30, 2009, 04:00:41 PM »
You're extracting the organic component into the DCM layer and trying to dissolve that component into DMSO-d6 or CDCl3?
Grad Student - Organic Chemistry
University of Alberta

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