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Topic: protecting group  (Read 5852 times)

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Offline profmsg

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protecting group
« on: February 19, 2008, 07:03:19 AM »
im using protecting group, AC2O for protecting of carboxylic groups in 2,6 dichloropyridine-4-carboxylic acid. i dont know the reaction condiditons and  how much AC2O will need for 100mg of 2,6dichloropyridine 4 carboxylic acid..

and full reaction mechanims as well

if anybody have idea plz reply me
thanks
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Offline AWK

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Re: protecting group
« Reply #1 on: February 19, 2008, 09:24:21 AM »
Mixed anhydride is rather an activating group
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Offline profmsg

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Re: protecting group
« Reply #2 on: February 20, 2008, 09:04:26 AM »

Mixed anhydride is rather an activating group
is that means -COOH will not be protected but activated and i will loose cooh group.

Offline AWK

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Re: protecting group
« Reply #3 on: February 20, 2008, 10:09:46 AM »
Mixed anhydrides are used in synthesis of many compounds, eg esters or  peptides.

http://content.arkat-usa.org/ARKIVOC/JOURNAL_CONTENT/manuscripts/2005/EJ-1500CP%20as%20published%20mainmanuscript.pdf
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