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Topic: electrophilic aromatic substitution  (Read 4653 times)

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dexangeles

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electrophilic aromatic substitution
« on: March 21, 2005, 01:54:08 AM »
Is there a reaction that allows for example ClCH2CH2OCH3 to attach directly to benzene?

something like a Friedel-Crafts alkylation

any links you can share would be appreciated :)
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Re:electrophilic aromatic substitution
« Reply #1 on: March 21, 2005, 02:24:43 PM »
I think you could use F-C for that reaction.  Otherwise, you might be able to do a Suzuki coupling or something.

Why not use phenyl Grignard and ethylene oxide followed by etherification with methyl iodide though?  That'd be easier, I think.
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Demotivator

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Re:electrophilic aromatic substitution
« Reply #2 on: March 21, 2005, 05:48:09 PM »
Yaahh, Suzuki coupling. I just might try that one of these nights!  :D
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Re:electrophilic aromatic substitution
« Reply #3 on: March 22, 2005, 05:45:41 AM »
Quote from: Demotivator on March 21, 2005, 05:48:09 PM
Yaahh, Suzuki coupling. I just might try that one of these nights!  :D

Heh, I've never done one myself, but people who have tell me that they tend to work pretty well.  I think that they are relatively easy as far as cross-coupling reactions go because the aren't particularly water sensitive, etc.
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