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Topic: Resolution of cis/trans-1,2-Diaminocyclohexane  (Read 3555 times)

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Offline tomraw

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Resolution of cis/trans-1,2-Diaminocyclohexane
« on: October 23, 2012, 01:15:40 AM »
Hi!
I need to saparete trans-isomer as monotartrate salt from cis/trans mixture...
Does anybody know how to determine purity of diamine after saparation?
Thanks
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Offline discodermolide

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Re: Resolution of cis/trans-1,2-Diaminocyclohexane
« Reply #1 on: October 23, 2012, 01:18:47 AM »
The most accurate way is to use HPLC, but you will require pure samples of each isomer.
The other way is 1H-NMR.
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Offline tomraw

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Re: Resolution of cis/trans-1,2-Diaminocyclohexane
« Reply #2 on: October 23, 2012, 04:09:30 AM »
 :'(
I don't have suitable HPLC column to saparate cis - trans  isomers....and it have IR detector so won't see any signal I think.
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Offline discodermolide

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Re: Resolution of cis/trans-1,2-Diaminocyclohexane
« Reply #3 on: October 23, 2012, 04:26:58 AM »
Then use NMR failing that a quantitative TTC may help
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Offline orgopete

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Re: Resolution of cis/trans-1,2-Diaminocyclohexane
« Reply #4 on: October 23, 2012, 11:45:25 PM »
Gas chromatography
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