December 09, 2024, 04:03:09 PM
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Topic: Wolff-Kischner reduction, does it work on amide and carbonxylic acid as well?  (Read 6484 times)

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Offline throllen

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I know it works on ketone and aldehyde, but what about amide and carbonxylic acid, ester???

Offline sjb

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I don't think so (but that doesn't mean no, necessarily).

Certainly with carboxylic acids I'd've thought you'd get hydrazium salts under the reaction conditions.

In any event, LiAlH4 reduction (or similar) would probably give the required amine or alcohol (from amide and acid/ester).

S

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