Topic: Wolff-Kischner reduction, does it work on amide and carbonxylic acid as well? (Read 6325 times)

throllen · « **on:** April 05, 2008, 10:41:17 PM »

I know it works on ketone and aldehyde, but what about amide and carbonxylic acid, ester???

sjb · « **Reply #1 on:** April 06, 2008, 03:07:00 PM »

I don't think so (but that doesn't mean no, necessarily).

Certainly with carboxylic acids I'd've thought you'd get hydrazium salts under the reaction conditions.

In any event, LiAlH₄ reduction (or similar) would probably give the required amine or alcohol (from amide and acid/ester).

S

Topic: Wolff-Kischner reduction, does it work on amide and carbonxylic acid as well? (Read 6325 times)

throllen

Wolff-Kischner reduction, does it work on amide and carbonxylic acid as well?

sjb

Re: Wolff-Kischner reduction, does it work on amide and carbonxylic acid as well?

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