November 27, 2022, 02:46:06 AM
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Topic: major product - grignard reaction  (Read 3169 times)

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Offline portugal

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major product - grignard reaction
« on: April 23, 2008, 04:33:08 AM »
if  i was to react phenyl butanoate and propylmagnesium bromide then i am going to get as my maijor product 4-heptanone.

Offline venkatjohnny

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Re: major product - grignard reaction
« Reply #1 on: April 23, 2008, 06:15:44 AM »
Hi,
it depends upon how many equivalents of Grignard u r going to use!!!! If u r using lesser equivalents u may end up with ketone, but in higher equivalents the major product will be tertiary alcohol( recently i've done one similar reaction). Since ketones are more reactive than esters, immediartely they will react further to form tertiary alocohols....have  a nice time :)

Offline superg

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Re: major product - grignard reaction
« Reply #2 on: April 23, 2008, 06:25:10 AM »
hello,
if U use only one eq of grignard, you should form the ketone and the tertiary alcohol, as a mixture of both 2>. but all depend of the reactivity of your initial ester...

Offline sjb

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Re: major product - grignard reaction
« Reply #3 on: April 24, 2008, 03:23:30 AM »
I'm getting a strange feeling of deja lu (sic)

http://www.chemicalforums.com/index.php?topic=24053

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