April 25, 2024, 06:08:33 PM
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Topic: Conversion of bromobenzenes to anilines, phenols and carboxylic acid  (Read 7336 times)

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Offline zq

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    • pmgb
Can anybody suggest ways to convert bromobenzenes to anilines, phenols and carboxylic acid?

Offline zq

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For anilines, Pd catalyzed bromo to amine substitution is known. Carboxylic acids can be obtained by Pd or Ni catalyzed carbonylations? Are any other methods available for the above transformations?

Offline affa

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for making benzoic acid from bromobenzenes, carboxylation of the Grignard reagent, PhMgBr, with CO2 is much cheaper and safer method than transition-metal catalyzed carbonylation (using CO).

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