Sorry, I will be more specific.
I meant the labwork. I always hear people saying that working on heterocyclic compounds, especially N-containing compounds, is difficult. People say that everyday is a frustration when working with heterocyclic compounds. Why such a notion has become popular? Is there any reasoning behind those, discouraging/may be true, statements.
Do you mean on paper difficult? Or actual labwork difficult? Right now the question is too vague, which is probably why no one responded...