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Topic: synthesis of reserpine  (Read 10158 times)

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haiph12

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synthesis of reserpine
« on: March 15, 2004, 09:44:44 AM »
Help me to complete the scheme

Edit: edited title for better indexing. Mitch
« Last Edit: April 24, 2004, 07:03:26 PM by Mitch »

Offline AWK

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Re:do you solve the problem
« Reply #1 on: March 19, 2004, 03:50:21 AM »
This problem was solved in 1956 (as far as i remeber the exact year) by RB Woodward (synthesis of RESERPINE)

AWK
AWK

haiph12

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Re:do you solve the problem
« Reply #2 on: March 20, 2004, 07:11:36 AM »
do you help me to post the solution of
synthesis or the Web of synthesis of RESERPINE
Thank You

Offline AWK

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Re:do you solve the problem
« Reply #3 on: March 22, 2004, 05:02:08 AM »
See source material in: J. Am. Chem. Soc. 78, 2023-5 (1956) or just abstract in Chemical abstract 50, 13967b (1957)
AWK
AWK

GCT

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Re:do you solve the problem
« Reply #4 on: March 22, 2004, 08:04:07 PM »
You should know what the first does...it is an oxidizing agent and apparently it has oxidized two localities according to the product formula.  

The second agent HIO4 is often used to oxidized diols, specifically alpha diols, cleave the carbon bond between the diol and oxidize each of these counterparts to the carboxylic acid.

CH2N2, is frequently used to create methyl esters from carboxlic acids...

I'll attempt the problem myself in detail later if I have the time.

haiph12

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Re:do you solve the problem
« Reply #5 on: March 23, 2004, 03:38:37 AM »
Thank
I've search the address:

http://poohbah.cem.msu.edu/courses/cem852/classics/Chapter4.pdf

so, I've solve this problem
Thank: AWK , GCT

Offline Mitch

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Re:do you solve the problem
« Reply #6 on: March 23, 2004, 03:49:23 AM »
Is it in Nicolaous' book "classics in organic synthesis"? I'll have to check when I get to lab.
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