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Topic: why reic acid is acid  (Read 4295 times)

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Offline timchai

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why reic acid is acid
« on: March 06, 2009, 09:00:20 PM »
i want to ask why it is , where is its ionizatble H atom , why it has PKa -3.xx , where acidic
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Offline timchai

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Re: why reic acid is acid
« Reply #1 on: March 06, 2009, 09:00:57 PM »
not uric acid
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Offline Borek

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Re: why reic acid is acid
« Reply #2 on: March 07, 2009, 04:09:50 AM »
I have no idea what reic acid is. I suppose I am not alone.
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Offline timchai

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Re: why reic acid is acid
« Reply #3 on: March 07, 2009, 08:40:21 PM »
en.wikipedia.org/wiki/Uric_acid
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Offline nj_bartel

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Re: why reic acid is acid
« Reply #4 on: March 07, 2009, 08:46:00 PM »
why would you say 'not uric acid?'

At any rate, it's acidic because it's conjugate base is stable - the carbonyl oxygen carries a large portion of the negative charge when the amine gets deprotonated.
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Offline timchai

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Re: why reic acid is acid
« Reply #5 on: March 07, 2009, 11:41:06 PM »
why N H can lose its H atom , why it is so acidic , ,can u use inductive effect to explain and show its conjugated base
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Offline macman104

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Re: why reic acid is acid
« Reply #6 on: March 08, 2009, 12:44:44 AM »
Quote from: timchai on March 07, 2009, 11:41:06 PM
why N H can lose its H atom , why it is so acidic , ,can u use inductive effect to explain and show its conjugated base
As nj said, it is due to the conjugate base being so stable.  You can observe the same thing when you look at acetone and acetylacetone.  I've drawn some pictures to help illustrate the idea for you.
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