Hi! Thanks! :)I did little search and I think that I understand mechanism now but still I didn't find answers to most of my questionsWhat's their origin? And did "first cell" contain genes for them?What if there would be a mutation and and some chaperonin would be nonfunctional? Would it be lethal?
now I read that ribosomes in prokaryotes don't have chaperonins function so it would be lethal for prokaryotes but I'm not sure for eukaryotes cause their ribosomes have that function ...so does that mean that most of mutations in genes for chaperones wouldn't be lethal?
And I read that mutation for hsp90 would be lethal in early embrionic stage....
Now do you know some diseases related to non functional chaperones? And if someone has idea about my previous questions, just an idea
ps most informations from :)http://www.chaperone.sote.hu/Examples.html