I had been under the assumption that when two different chemical methods--each relying on a different independent chemical principle--are used to analyze a common sample, then the result of the analysis ought be nearly identical.
For example, if the concentration of a certain drug metabolie is measured in urine via GC/MS to be 100 ng/uL; then when that same sample is analyzed by HPLC it SHOULD be found to be 100 ng/uL. Using the same calibration stds etc... Isn't this correct thinking? Pls address any misconceptions that I may be operating under. Looking fwd to your posts.