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Topic: hydrocortisone 21-butyrate transesterification  (Read 2149 times)

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Offline rothko

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hydrocortisone 21-butyrate transesterification
« on: November 07, 2009, 04:05:54 PM »
Hi there, I was hoping someone could help me. 

In aqueous solution dissolved hydrocortisone-21-butyrate rearranges to form hydrocortisone-17-butyrate (degradation product).  I think the process is intramolecular transesterification, but I am not sure.  I have heard that addition of an omega-6-fatty acid stops this degradation occuring.  Does anyone know how this could be.

Thanks

Rothko

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