March 28, 2024, 12:46:41 PM
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Topic: synthesis of 5-(1H-Pyrazol-4-yl)thiophene-2-carboxylic Acid -----Need your help  (Read 2725 times)

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Offline wallysheng

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We have a project recently need to synthesize 5-(1H-Pyrazol-4-yl)thiophene-2-carboxylic Acid  for about 10-20grams.
Has anybody done this compound before? Do you have any suggestion or literature for us to refer to?

Thank you!

Offline sjb

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What about Suzukis or similar with 4-halopyrazole and 5-boronic esters of thiophene-2-carboxylic acid?

Seems that aryl bond is fundamental to making this class of molecule.

How did the difluorobicycle work out - I note it's not on your website?

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