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Topic: Using EDAC in a carboxylic acid with amine reaction to form an amide?  (Read 6044 times)

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Offline vivioo7

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Has anyone done this?  I'd trying to figure out the reaction conditions.  Thanks for any help

Offline lmlh

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Re: Using EDAC in a carboxylic acid with amine reaction to form an amide?
« Reply #1 on: January 04, 2010, 07:01:08 AM »
it is ok in dry dichloromethane at RT

Offline Zainb

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Offline xiaoruan

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Re: Using EDAC in a carboxylic acid with amine reaction to form an amide?
« Reply #3 on: January 05, 2010, 11:20:16 AM »
dissolve the acid(dry CH2Cl2 or dmf as solvent), add in the  EDAC in ice-bath and then add in amine ,half an hour later remove the ice-bath ,stir in RT for overnight,remove the solvent under reduced pressure ,dissolve the residue with EtOAc and freeze for half an hour in refrigeratory ,filter out the EDAC, remove the EtOAc the residue was isolated
by column chromatographyon a silica gel column

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