[Harold.Han]

I want to have a very simple reaction between -NH2 and methyl ester in MeOH.

Because the compound containing Methyl ester has sugar rings and double bonds, I can not do an intensive reaction.

What I really want to do is put Et3N in the system and react at RT.

Can somebody tell me whether it will work?

Thanks!

[OC pro]

It will react extremely slowly. More better is to convert the ester to acid. Then you can use standard peptide coupling reagents (e.g. EDC, TBTU and so on).