[shrikantvarma]

what is difference between LC/MS & GC/MS?

[JGK]

The reading starts here:

LC/MS http://en.wikipedia.org/wiki/Liquid_chromatography-mass_spectrometry

GC/MShttp://en.wikipedia.org/wiki/GC-MS

[Golden_4_Life]

...but if you are in the process of deciding which is the better instrument system to purchase, then choose the GCMS as it is easier to operate, costs less, and generally has fewer maintenance issues the require an outside service rep engineer (most GCMS problems you can fix on your own).

[JGK]

...but if you are in the process of deciding which is the better instrument system to purchase, then choose the GCMS as it is easier to operate, costs less, and generally has fewer maintenance issues the require an outside service rep engineer (most GCMS problems you can fix on your own).

. And pretty useless if your analyte is non-volatile, unless you spend an age on derivatisation of your samples to get them to run on a GC. GC-MS and LC-MS are not generally intercahngeable options.

[Golden_4_Life]

There are myriad derivitizing agents, so no need to fretfully dole over this issue.