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Topic: dehalogenation of chloropyridine  (Read 2884 times)

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Offline shrikantvarma

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dehalogenation of chloropyridine
« on: August 17, 2010, 01:25:58 PM »
i want to dehalogenate substituted pyridine the halogen is chloro group on pyridine i tried with zn/acetic acid & PD/C/H2 but no
good result could anybody suggest me some good reagent for the same??
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Offline stewie griffin

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Re: dehalogenation of chloropyridine
« Reply #1 on: August 17, 2010, 03:42:49 PM »
Perhaps try Rieke zinc? Maybe your zinc just wasn't activated enough.
http://en.wikipedia.org/wiki/Rieke_metals
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Offline Cancer Boy

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Re: dehalogenation of chloropyridine
« Reply #2 on: August 17, 2010, 06:12:36 PM »
If selectivity isn't an issue, you could try a simple Grignard degredation. Form the Grignard from chloropyridine, then quench it with water or methanol.
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Offline g-bones

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Re: dehalogenation of chloropyridine
« Reply #3 on: August 17, 2010, 07:43:19 PM »
Pearlman's catalyst is good for hydrogenolysis, its worth a shot.
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