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Topic: cyanohydrin from O-silylated cyanohydrin  (Read 3487 times)

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Offline shrikantvarma

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cyanohydrin from O-silylated cyanohydrin
« on: September 28, 2010, 11:55:47 AM »
how to prepare cyanohydrin from O-silylated cyanohydrin ??

Offline discodermolide

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Re: cyanohydrin from O-silylated cyanohydrin
« Reply #1 on: September 28, 2010, 12:42:39 PM »
how to prepare cyanohydrin from O-silylated cyanohydrin ??

Try HF/acetonitrile at 0°C-RT
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Offline shrikantvarma

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Re: cyanohydrin from O-silylated cyanohydrin
« Reply #2 on: September 28, 2010, 12:44:24 PM »
can we use aq.hydrochloric acid instead of HF

Offline discodermolide

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Re: cyanohydrin from O-silylated cyanohydrin
« Reply #3 on: September 28, 2010, 01:43:09 PM »
can we use aq.hydrochloric acid instead of HF
No HF is more selective. With HCl you may eliminate to get the alpha-beta unsaturated nitrile.
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