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Topic: witting reaction  (Read 3937 times)

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Offline shrikantvarma

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witting reaction
« on: October 16, 2010, 07:18:17 AM »
is it possible to perform witting reaction of alpha halo ketone ( in my case i using alpha bromomethyl isopropyl ketone) i am getting some unknown products pls explain??

Offline discodermolide

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Re: witting reaction
« Reply #1 on: October 16, 2010, 07:33:07 AM »
is it possible to perform witting reaction of alpha halo ketone ( in my case i using alpha bromomethyl isopropyl ketone) i am getting some unknown products pls explain??
What is your Wittig reagent? You may get attack at the carbonyl followed by epoxide formation similar to sulphur ylids
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Offline shrikantvarma

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Re: witting reaction
« Reply #2 on: October 16, 2010, 07:48:38 AM »
Thanks for reply.
i used methyledene triphenyl phosphorane as witting reagent?? can i brominate after witting reaction ?? will it work as i think alkene formation there might be problem in bromination??

Offline discodermolide

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Re: witting reaction
« Reply #3 on: October 16, 2010, 09:10:02 AM »
Thanks for reply.
i used methyledene triphenyl phosphorane as witting reagent?? can i brominate after witting reaction ?? will it work as i think alkene formation there might be problem in bromination??

If you get the olefin you can brominate it under normal conditions.
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Offline shrikantvarma

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Re: witting reaction
« Reply #4 on: October 16, 2010, 02:20:51 PM »
thanks,
will bromination will not go to alkene which will be the ideal condition???

Offline discodermolide

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Re: witting reaction
« Reply #5 on: October 16, 2010, 06:02:52 PM »
thanks,
will bromination will not go to alkene which will be the ideal condition???

I said above, if you get the olefin (alkene) it will brominate
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