[Peacock]

Dear all,

While developing an analytical method for GC, I have realised that one of the reagents contains traces of my analyte from the factory. It seems impossible to get this reagent impurity free.
Therefore my question is:

How valid would it be as a method if I subtract the blank peak area from any sample?

Does this impair the whole method and, therefore I should be thinking of finding another one?

Would it be ok if I draw a calibration curve crossing the ordinate axis above 0?

What would you do in my situation?

Regards

[Stepan]

This is very common. You need to subtract solvent blank from your result. Be sure you take it into account when you estimate your detection limit.

[vijayak]

 

[ruthfabiny]

This was helpful. Thanks ,
Ruth Fabiny