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Topic: Benzylamine Impurity  (Read 6245 times)

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Offline AC Prabakar

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Benzylamine Impurity
« on: January 11, 2011, 12:08:14 AM »
I am observing some non polar impurity(by TLC) in benzylamine which stored about 2 months.As my intention is not to investigate this impurity i couldn't concentrate this area!
Anyway i didn't checked for new lot.

It will be helpful if anybody could give a clue!!!
Thanks in advance!
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Offline sjb

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Re: Benzylamine Impurity
« Reply #1 on: January 11, 2011, 02:27:32 AM »
Quote from: AC Prabakar on January 11, 2011, 12:08:14 AM
I am observing some non polar impurity(by TLC) in benzylamine which stored about 2 months.As my intention is not to investigate this impurity i couldn't concentrate this area!
Anyway i didn't checked for new lot.

It will be helpful if anybody could give a clue!!!
Thanks in advance!

Does it interfere with your reaction? The only real thing I can think of is perhaps some oxidised form, but these would be more polar than the parent I think.
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Offline AC Prabakar

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Re: Benzylamine Impurity
« Reply #2 on: January 11, 2011, 02:38:18 AM »
No it seems to be that is not interfering with my reaction(it is stagnant during and after the completion of starting material).


Quote from: sjb on January 11, 2011, 02:27:32 AM

The only real thing I can think of is perhaps some oxidised form, but these would be more polar than the parent I think.

Yes! i too guessing the same, of course after oxidation, the resultant moiety may react with benzylamine and can give amide!!

Correct me if i am wrong...
But surprisingly i couldn't see any literature supporting my words/guessing!!!!
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Offline Jesse2024

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Re: Benzylamine Impurity
« Reply #3 on: January 11, 2011, 07:41:43 AM »
You could possibly distill or separate with a column to increase purity, I'm guessing since you can see there are two distinct compounds using TLC that separation using a column would be possible.
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Offline ardbeg

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Re: Benzylamine Impurity
« Reply #4 on: January 11, 2011, 08:35:53 PM »
is there any whitish crust around the rim of the bottle?  it can react with CO2 to form the carbamic acid.
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