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Topic: synthesis of N-substituted Imidazole/pyrazole  (Read 2632 times)

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Offline malviyangr

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synthesis of N-substituted Imidazole/pyrazole
« on: April 22, 2011, 07:51:02 AM »
Hi to all.
I want to make N-substituted pyrazole/imidazole using alpha,alpha'-para bromo xylene and pyrazole/imidazole. I want to use the NaOH-THF solvent system whether it is appropriate or not? And in the same solvent system, whether I should take dried THF or ordinary one?
or Can we use methanol instead of THF above , will it react with my bromo-compound.(One has used methanol with chloro compound).
Suggest any other solvent if anyone has done this reaction?
Thanks for any help...


Offline Dan

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Re: synthesis of N-substituted Imidazole/pyrazole
« Reply #1 on: April 22, 2011, 07:57:41 AM »
For the convenience of others, I have attached the scheme from the .doc below.

You'd probably be better off with a non-nucleophilic base.
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Offline azmanam

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Re: synthesis of N-substituted Imidazole/pyrazole
« Reply #2 on: April 22, 2011, 08:29:49 AM »
I've never run this reaction before, but my first thought is just to use pyridine as the solvent.  it will also be the base.
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