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Topic: How to make this reaction happen  (Read 4435 times)

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Offline key435

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How to make this reaction happen
« on: July 25, 2011, 12:15:21 PM »
I saw a strange reaction. And I do not know how it happens ? It's change one group from -OH to -CHO but other -OH don't change. How can it happen ? I don't understand. Can you give me some explanations about that. And give me some reactants using for this reaction. Thanks so much.


Offline discodermolide

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Re: How to make this reaction happen
« Reply #1 on: July 25, 2011, 12:23:19 PM »
I saw a strange reaction. And I do not know how it happens ? It's change one group from -OH to -CHO but other -OH don't change. How can it happen ? I don't understand. Can you give me some explanations about that. And give me some reactants using for this reaction. Thanks so much.



You have one of the OH groups as tertiary, this cannot be oxidized by normal processes!
The primary alcohol can be oxidized using the usual reagents for this process, which I'm sure you can find them by yourself.
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Offline key435

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Re: How to make this reaction happen
« Reply #2 on: July 26, 2011, 11:49:26 AM »
Sorry for asking that question. It's so simple.  ;D. But actually, I don't understand clear about the mechanism of the reaction. And I really know some reactants such as: CrO3, KMnO4, or CuO... But if you know excactly about that reaction, could you give me some information about it, and I want to know some more reactants and the conditions to make it happen. Thanks for your attention. ^^.

Offline discodermolide

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Re: How to make this reaction happen
« Reply #3 on: July 26, 2011, 12:22:26 PM »
Sorry for asking that question. It's so simple.  ;D. But actually, I don't understand clear about the mechanism of the reaction. And I really know some reactants such as: CrO3, KMnO4, or CuO... But if you know excactly about that reaction, could you give me some information about it, and I want to know some more reactants and the conditions to make it happen. Thanks for your attention. ^^.
Look up oxidation of primary alcohols in wikki. Some reagents are bleach/tempo, Dess-martin, SO3/pyridine, Swern oxidation, Pfitzner- Moffat and so on.
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