[peptideismylife]

Hi,

I was wondering about the polarity of azide group. I know the aminogroup is a very good polar group but what about azide group? has it weakly polarity?

[Sepelio]

The azide does have polarity. If you look at the resonance structure you can push electrons around and see it. The wiki page actually has some decent diagrams on it:
http://en.wikipedia.org/wiki/Azide

[discodermolide]

Hi,

I was wondering about the polarity of azide group. I know the aminogroup is a very good polar group but what about azide group? has it weakly polarity?

Are you talking about chromatographic polarity? If so it is less polar than the amino group.

[Honclbrif]

I've done bromide to azide swaps and seen almost no change in Rf, even by HPLC.

[discodermolide]

I've done bromide to azide swaps and seen almost no change in Rf, even by HPLC.

Sure, I agree,  but amino to azide is a big difference in chromatographic polarity