[medist]

Hello can anybody tell me does a bicyclic bromo compound with Br at bidgehead position react in Pd-catalysed couplings

[Honclbrif]

Which Pd-catalyzed coupling are you thinking about? There are a few of them...

[medist]

Which Pd-catalyzed coupling are you thinking about? There are a few of them...


for example in Suzuki coupling or Stille coupling

[Åke]

You're probably looking for Kumada coupling. However, the compeating β-hydride elimination may pose a problem in your case. There are methods aimed at preventing this side-reaction, a recent example: Joshi-Pangu, A.; Wang, C-Y.; Biscoe, M. R. Nickel-Catalyzed Kumada Cross-Coupling Reactions of Tertiary Alkylmagnesium Halides and Aryl Bromides/Triflates J. Am. Chem. Soc., 2011, 133, 8478–8481 http://pubs.acs.org/doi/abs/10.1021/ja202769t  Note that 2 mol equivalents of RMgX is used.