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Topic: Pd-catalyzed coupling: possible catalyst posions.  (Read 2960 times)

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Offline asa029

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Pd-catalyzed coupling: possible catalyst posions.
« on: September 07, 2011, 08:27:38 AM »
Are there any well-known posions/deactivators for Pd-catalyzed coupling reactions? I think I read once that MeOH might deactivate such reactions, but I'm not able to find any articles on the subject. Does anyone have any input?

Offline OC pro

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Re: Pd-catalyzed coupling: possible catalyst posions.
« Reply #1 on: September 08, 2011, 11:54:46 AM »
MeOH is complete nonsense. As Pd poisons/deactivators are actually known:
Sulfur-containing substances (there is a hydrogantion using diphenylsulfide as poison), amines and of course air (leading to Pd(II)-species).

Offline fledarmus

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Re: Pd-catalyzed coupling: possible catalyst posions.
« Reply #2 on: September 08, 2011, 12:12:34 PM »
Lead salts and quinoline are fairly widely used

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