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Topic: Help wrt conversion of alcohol and aldehyde to acid  (Read 2912 times)

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Offline saimark143

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Help wrt conversion of alcohol and aldehyde to acid
« on: September 19, 2011, 11:33:24 AM »
Hai All,

I am working in the field of natural products and as part of my work, i need to convert a primary alcohol and an aldehyde into acid group. My molecule is of phenoxazone type with the substituents of primary alcohol and aldehyde at position 9. Position 1 has -COOH group and position 3 has -NH2 group.

Can anyone help me out wrt the conversion using the extract (wherein the compounds are present).

Kindly see the attached document.

Thanking you


Offline Dan

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Re: Help wrt conversion of alcohol and aldehyde to acid
« Reply #1 on: September 21, 2011, 01:01:31 PM »
A popular and mild sequence for the oxidation of alcohols to acids is oxidation to the aldehyde with Dess-Martin periodinane, and then oxidation of the aldehyde to the acid by a Pinnick oxidation.

There are many methods though, the question is quite broad. Try a literature search to narrow down your options.
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