[Kaladiscope]

Hi colleagues,

I'm planning to run a reaction between an ethylene glycol and P(NiPr), in order to synthesize a phosphite. Do you think that is possible to carry out without adding a base? if the answer is yes, how it calls this reaction?

Thanks!

[discodermolide]

Hi colleagues,

I'm planning to run a reaction between an ethylene glycol and P(NiPr), in order to synthesize a phosphite. Do you think that is possible to carry out without adding a base? if the answer is yes, how it calls this reaction?

Thanks!

Yes this should work, I don't think the reaction has a name. You will eliminate two moles of HN(iPr)2 and form the cyclic compound.
You into phospholipids?

[Kaladiscope]

Yeah, i'm into phospholipids, doing stuff like linking to ethyleneglycol units.

But how can work the reaction? since this phosphorous is a nucelophile, it should attack the alcohol. But I can't see it without a base.

[discodermolide]

Yeah, i'm into phospholipids, doing stuff like linking to ethyleneglycol units.

But how can work the reaction? since this phosphorous is a nucelophile, it should attack the alcohol. But I can't see it without a base.

Just add the phosphinamidate to the ethylene glycol. The O atoms are nucleophillic enough to displace the di-isoproplylamine.
Done it many times.