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Topic: action of grignard reagent with amide  (Read 6610 times)

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Offline furaniki18

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action of grignard reagent with amide
« on: December 17, 2011, 09:41:20 AM »
what is the mechanism behind reaction between grignard reagent and amide? does it form an alkane?

Offline Dan

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Re: action of grignard reagent with amide
« Reply #1 on: December 17, 2011, 05:24:49 PM »
No, alkanes are not formed.

The product depends on the amide; primary and secondary amides react differently compared to tertiary amides.

What do you think would happen if you treated a primary or secondary amide with a Grignard?

For tertiary amides, the mechanism begins in an analogous fashion to the reaction of an ester with a Grignard. Hint: Weinrieb amide

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