March 29, 2024, 03:46:42 AM
Forum Rules: Read This Before Posting


Topic: action of grignard reagent with amide  (Read 7009 times)

0 Members and 1 Guest are viewing this topic.

Offline furaniki18

  • Regular Member
  • ***
  • Posts: 35
  • Mole Snacks: +0/-0
action of grignard reagent with amide
« on: December 17, 2011, 09:41:20 AM »
what is the mechanism behind reaction between grignard reagent and amide? does it form an alkane?

Offline Dan

  • Retired Staff
  • Sr. Member
  • *
  • Posts: 4716
  • Mole Snacks: +469/-72
  • Gender: Male
  • Organic Chemist
    • My research
Re: action of grignard reagent with amide
« Reply #1 on: December 17, 2011, 05:24:49 PM »
No, alkanes are not formed.

The product depends on the amide; primary and secondary amides react differently compared to tertiary amides.

What do you think would happen if you treated a primary or secondary amide with a Grignard?

For tertiary amides, the mechanism begins in an analogous fashion to the reaction of an ester with a Grignard. Hint: Weinrieb amide

My research: Google Scholar and Researchgate

Sponsored Links