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Topic: Nitration of Benzimidazole  (Read 3467 times)

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Offline Dodeca wolfram

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Nitration of Benzimidazole
« on: April 05, 2012, 12:11:03 PM »
Hello
I have been doing the nitration of this compound despite the fact that the reaction time and the volumes of the nitration mix were varying.

So I have made the nitration reagent  1:1 (HNO3/H2SO4) and I made two reactions one went on for 5 minutes total the other 2 hours. The temperature was kept under 50 Celsius to restrict the formation of dinitro compounds.

The product was matching roughly the melting point of the target compound, but i have to yet determine if the Major product has the nitro group on the 5 position . The outcome was very similar for both reactions how ever afther measuring IR spectra the nitro group was not clearly there . There were band that could belong to the nitro group but in comparison to other compounds with nitro substitute. I was comparing the shape and positions on 5-nitro-1,10-phenantroline .

So my question is mostly about if my nitration and maybe about the nitro IR bands that seem to be off .

Offline Honclbrif

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Re: Nitration of Benzimidazole
« Reply #1 on: April 05, 2012, 10:02:41 PM »
I have no idea what you're asking.

Is your question about the nitration procedure? The regioselectivity? Or interpretation of the IR spectrum and good standards to compare it to?
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