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Topic: conversion of aliphatic terminal alkyl chains to azide  (Read 7515 times)

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Offline simonraj

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Re: conversion of aliphatic terminal alkyl chains to azide
« Reply #15 on: April 06, 2012, 05:39:56 AM »
OK, thank you.

An alternative to TEL is Methyl Tertiary Butyl Ether.


I have now idea if it will work. But I do not advise the use of tetraethyl lead, which is an extremely toxic substance.
Anyway the higher the temperature the greater the chance of side reactions.



Offline discodermolide

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Re: conversion of aliphatic terminal alkyl chains to azide
« Reply #16 on: April 06, 2012, 05:45:25 AM »
OK, thank you.

An alternative to TEL is Methyl Tertiary Butyl Ether.


I have now idea if it will work. But I do not advise the use of tetraethyl lead, which is an extremely toxic substance.
Anyway the higher the temperature the greater the chance of side reactions.




I fail to see how MTBE can be an alternative to tetraethyl lead!!!!!
As I said many times before you will get a mixture using these conditions.

Can you not utilize two starting materials and couple them?
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Offline AWK

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Offline orgopete

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Re: conversion of aliphatic terminal alkyl chains to azide
« Reply #18 on: April 07, 2012, 03:19:32 AM »
Why not start with an alpha olefin, like 1-dodecene?
http://en.wikipedia.org/wiki/Linear_alpha_olefin
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