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Topic: why does paracetamol/acetaminophen have a high melting point?  (Read 6194 times)

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Offline grangerfor222

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why does paracetamol/acetaminophen have a high melting point?
« on: August 04, 2012, 03:44:31 AM »
is it because of the amide functional group as it requires high energy to break the bonds apart?

Offline discodermolide

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Re: why does paracetamol/acetaminophen have a high melting point?
« Reply #1 on: August 04, 2012, 05:13:52 AM »
is it because of the amide functional group as it requires high energy to break the bonds apart?

It may be because of the hydrogen bonds formed between the phenol OH and the amide.
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Offline grangerfor222

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Re: why does paracetamol/acetaminophen have a high melting point?
« Reply #2 on: August 04, 2012, 04:19:18 PM »
ah ok thank you. so overall, paracetamol has hydrogen bonding?

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Offline Enthalpy

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Re: why does paracetamol/acetaminophen have a high melting point?
« Reply #4 on: August 08, 2012, 01:48:53 PM »
Any "...ol" has hydrogen bonds, which are strong hence raise the melting and boiling points. The hydrogen influenced by oxygen (or by nitrogen also) can bond with an oxygen or nitrogen.

Hydrogen bonds are stronger than other forces between molecules. That's why water, methanol... have higher melting and boiling points than methane, ethane...

Any finer prediction would be very dificult and depend on the precise shape of the molecule and stacking of them.

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