The use of water as a solvent will cause a reverse reaction.
Areas of high pressure, will it affect where using glass piping is appropriate?
We are planning to use fractional distillation to seperate:
-unreacted materials (acetic-anhydride, salicylic acid)
-by-product(acetic acid, in the sense that it's not going to be used for 'this' process)
Will there be any problems to the seperation such as difficulty maintaining a specific chemical compound after it is condensed?
(I'm not sure hot to say it)
Will any compounds have trouble condensing back after evaporation?
Glass should be ok because you only make the transfers with this material. Pressure is applied afterwards.
Fractional distillation of these materials will not work, compare boiling points, you will ned a good vacuum and an efficient column, the lower the BPt. the worse the fractionation.
An extractive work-up is better. If you use toluene, for example, as the reaction solvent you can add water and wash out the acids with bicarbonate (lots of CO2
. produced). Separate the layers and evaporate the toluene, azeotropic drying will take place, hopefully the product will crystallise.
I have no idea if this works in toluene, lets assume it does.