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Topic: Why is magnesium an NMDA antagonist?  (Read 1566 times)

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Offline mycotheologist

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Why is magnesium an NMDA antagonist?
« on: August 31, 2012, 09:54:46 PM »
The NMDA receptor is a ligand gated non selective cation channel. It allows Na+ and to a lesser extent Ca2+ and K+ to pass through. I read that Mg2+ clogs up the pore. Why would Mg2+ block the channel but not Ca2+? Ca2+ is larger so I'd expect that to be more likely to block an ion channel. Is it because Mg2+ is more electronegative than Ca2+?

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