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Topic: Why acetaminophen is comparatively less soluble than Aspirin in dicholoromethane  (Read 2007 times)

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Offline Erik

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Why acetaminophen is comparatively less soluble than Aspirin in dicholoromethane
« on: September 22, 2012, 05:03:15 AM »
according to theory, hydrogen bonding > permanent dipole- dipole > temporary dipole induced dipole , acetaminophen and aspirin both possesses hydrogen bonding, so in dicholoromethane , where the predominant forces of attraction is permanent dipole dipole , why is acetaminophen less soluble than aspirin in dicholomethane? Help appreciated :)
« Last Edit: September 22, 2012, 05:16:01 AM by Erik »
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Offline PhDoc

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Re: Why acetaminophen is comparatively less soluble than Aspirin in dicholoromethane
« Reply #1 on: September 26, 2012, 03:49:48 PM »
What functional group is present in acetaminophen that is not present in aspirin? What do you know about this functional group? Also, what might you infer about the crystal packing forces in acetaminophen vs. aspirin? Are both items alluded to contributing equally, or does one outweigh the other? Why?
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