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Topic: Aniracetam Synthesis Help  (Read 1932 times)

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iamabeginner

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Aniracetam Synthesis Help
« on: January 30, 2013, 02:31:19 PM »
So on its wikipedia page it mentions using p-anisoyl chloride, 2-pyrrolidone, and triethylamine. Now, is TEA a catalyst here? Can NaOH be substituted for it?

Basically, what a some more details to its synthesis. Is HCl generated? Can the TEA be distilled out once the reaction completes? Help me here, please.

Offline Arkcon

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Re: Aniracetam Synthesis Help
« Reply #1 on: January 30, 2013, 02:48:08 PM »
Generally, no, you can't substitute an strong mineral base for a weak organic base in an organic synthesis.  If you have a few organic chemistry classes, you might know some reasons why.  Can you suggest some?  The Forum Rules (in RED at the top of every page) specify this -- this forum is to help students learn topics.  This isn't a kiddie drug synthesis forum.  That's also in the rules, we don't give hints towards self medication in this forum, even for still-legal-in-some-places-totally-not-a-party-drug-plz-help topics.
Hey, I'm not judging.  I just like to shoot straight.  I'm a man of science.

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