Dear all member,
As I know, imine could be easily formed by reaction of aldehyde and amine, but when i carry out this reaction, it doesnt work and I'm really confused.
My reaction conditions: starting materials (1eq), amine (1.5 eq), MgSO4 (4eq), dry Ch2Cl2 mixed together and kept at 30 -40oC, put overnight but when I check on TLC, there's still starting material left. Even when I try to treat the reaction (just to obtain the product), purify by CC, I can not have desire product. Dont know why because this's a simple reaction??
And I also try this reaction using microwave, but no effective :-<
Is there any helpful opinion? I'm quite confused. And actually, i used directly starting material (aldehyde) from previous reaction, without treatment ( using oxalyl chloride, DMSO, dry CH2Cl2)
Thank you a lot for your comments!