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Topic: NHS ester react with amide?  (Read 2056 times)

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Offline bialy

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NHS ester react with amide?
« on: November 15, 2012, 02:16:40 PM »
Can an NHS ester react with an amide to form a covalent bond?
I would like to know if a crosslinker with an NHS ester can react with a poly(acrylamide) gel.
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Offline bialy

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Re: NHS ester react with amide?
« Reply #1 on: November 15, 2012, 08:31:58 PM »
this is not a homework question, rather something I am dealing with in lab!
I was assuming the amide should be stable and cannot react with the NHS ester. I am wondering if there are any mechanisms by which the amide can be nucleophilic enough to attack the NHS ester and react with it? I do not think there are any other groups present in the polyacrylamide gel that could react with the NHS ester.
Thank you!
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