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Topic: how to increaseThiol yields  (Read 3275 times)

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Offline GSR

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how to increaseThiol yields
« on: January 24, 2006, 10:35:19 AM »
Hi,

does anyone know the procedure/literature reference to increase the yields of thiols which are obtained by reacting benzyl chloride derivatives and thiourea.

thanks in advace

GSR

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Re:how to increaseThiol yields
« Reply #1 on: January 29, 2006, 02:37:44 PM »
I don't have a reference, but one common way is to add sodium iodide or tetrabutylammonium iodide.  Those salts form some benzyl iodide in solution, which is a lot more reactive that the chloride version.

Offline GSR

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Re:how to increaseThiol yields
« Reply #2 on: January 30, 2006, 08:44:47 PM »
thanks a lot I will try this method.

GSR

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