[peptideismylife]

Hey people,

I am looking for a base cleavable protecting group that fulfill the following features:

1. Cleavable under NaOH but not under nucleophilic bases (piperidine or DIPEA)
2. Stable under TFA.
3. Easy to remove. No long reaction times.

I was thinking in TFA as a protecting group, but I think that it is really hard to removed and u need long reaction times.

Any suggestion?

[discodermolide]

What are you going to protect?

[peptideismylife]

Oh sorry,

I am gonna protect an amine!

[OC pro]

Go with Fmoc.