But is my argument reasonable? I am very curious what you think as your knowledge of organic chemistry (in my eyes) is AMAZING!
1) Thioketene generation occurs best at -78°C. So once I create my thioketene I trap it with an amine to create the corresponding thioamide.
2) I would like to create a thiolactam, so I undergo the reaction intramolecularly with an amine functionality at -78°C and find that my thiolactam is not produced.
3) I realize that this might be a thermodynamic problem. Most of the time heat is required for cyclization. (NOT SURE IF THIS IS VALID POINT)
4) I decide to do the cyclization reaction at 70°C and there is no reaction.
5) I decide to go back to step 1) and generate a thioketene at 70°C and react it with an amine to create a thioamide... no reaction.
6) My final argument is that in order to create a thiolactam, heat is required, and because thioketenes are best generated at -78°C, the creation of a thiolactam is not possible in this way. A different method must be taken where the generation of a thioketene be done at higher temperatures.
Thoughts on this argument?