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Topic: Lys-NH2 + LAH  (Read 1539 times)

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Offline skiddum

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Lys-NH2 + LAH
« on: May 22, 2013, 05:54:45 PM »
I am trying to synthesize a triamine in the cheapest and easiest way possible. The underlying chemistry is condensation with a dione from adjacent amines to form an aromatic system, then have an alkyl tail/pendant/tether with a free primary amine. This requires something like 1,2,6-triaminohexane.

The simplest way I can seem to figure out how to do this is start with lysine, convert the COOH to a CONH2 (carboxylate to amide) and then reduce the carbonyl with LAH. Presto, a triamine! Problem is, after some literature searching, I'm not sure that this will work as lots of papers in peptide chemistry seem to imply the formation of amino alcohols.

Anyone ever use LAH with amino acids that have been converted to alpha-amide?

Offline camptzak

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Re: Lys-NH2 + LAH
« Reply #1 on: May 23, 2013, 12:36:49 AM »
show me a picture or give me an IUPAC name of the compound you are trying to synthesize
"Chance favors the prepared mind"
-Louis Pasteur

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