[hellomynameis]

When Synthesizing LSD from Lysergic acid... the OH from the carboxylic acid group is replaced with diethlyamine  creating Lysergic acid diethylamide.

Why would the addition of this amine make it more lipid soluble and are there any other significances about the amide group in LSD?

[RaInBowDaSh1488]

When Synthesizing LSD from Lysergic acid... the OH from the carboxylic acid group is replaced with diethlyamine  creating Lysergic acid diethylamide.

Why would the addition of this amine make it more lipid soluble and are there any other significances about the amide group in LSD?

Are you seriously asking why an alkyl amide would be more lipophilic then a carboxylic acid?

Were you on LSD when you posted this?

[camptzak]

When Synthesizing LSD from Lysergic acid... the OH from the carboxylic acid group is replaced with diethlyamine  creating Lysergic acid diethylamide.

Why would the addition of this amine make it more lipid soluble and are there any other significances about the amide group in LSD?

Are you seriously asking why an alkyl amide would be more lipophilic then a carboxylic acid?

Were you on LSD when you posted this?

it has to do with polarity, if you take some chemistry classes or read some books it will become clear. however the real intent of your question is obvious, and this is one of the only sites where we can't talk about drug synthesis. to be honest i'm surprised this thread isn't locked already
there are plenty of other sites where they discuss this stuff openly, and you will probably have better luck there.

[Borek]

So far this thread is not about LSD synthesis, but about simple properties of a large molecule.

[408]

Because alkyl - substituted amides are far less polar than a carboxylic acid.