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Topic: C-N heterocyclic dephenylation.  (Read 1954 times)

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Offline 408

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C-N heterocyclic dephenylation.
« on: September 17, 2013, 09:03:47 PM »
I have a rather electron poor heterocycle that I am building up. The easy synthetic route will leave it phenyl-substitued. The difficult route, benzyl substituted.  Obviously benzyl is easy to remove.  But what about phenyl?  I have seen a couple hardcore dephenylations using stuff like sodium in liquid ammonia, but is there anything easier?

thanks,
408.

Offline 408

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Re: C-N heterocyclic dephenylation.
« Reply #1 on: September 19, 2013, 12:14:15 AM »
p-methoxysubstituted phenyl can be removed with CAN :)

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